The band's current lineup consists of Gillespie, Andrew Innes (guitar), Martin Duffy (keyboards), Simone Butler (bass), and Darrin Mooney (drums). Barrie Cadogan has toured and recorded with the band since 2006 as a replacement after the departure of guitarist Robert "Throb" Young.
Primal Scream had been performing live from 1982 to 1984, but their career did not take off until Gillespie left his position as drummer of The Jesus and Mary Chain. The band were a key part of the mid-1980s indie pop scene, but eventually moved away from their jangly sound, taking on more psychedelic and garage rock influences, before incorporating a dance music element to their sound with their 1991 album Screamadelica, which broke them into the mainstream. Their latest album Chaosmosis was released on 18 March 2016.